EGFR and glioblastoma: At the same time, the enhancer (chr7: 54881593–54882643) related to the EGFR gene had significantly higher acetylation and lower DNA methylation in DA and GBM/pGBM samples than in PA (p < 0.01, Wilcoxon test; Spearman correlation of enhancer DNA methylation and H3K27 acetylation rho = − 0.5, p = 0.17, n = 12 samples, , Supplementary Fig. S5H,I).