According to TCGA data, half of the genes contacting differentially acetylated and differentially DNA-methylated enhancers, namely GLI3, ITGB3BP, DNAH11, ADGRA1 and ADGRF5P1 were found to be prognostic for patients’ survival (log-rank test p < 0.0001, in the TCGA dataset for WHO GIII and GIV glioma patients; Supplementary Table S13, Supplementary Fig. S6A–E). This evidence concerns the gene GLI3 and central nervous system cancer.