In these studies, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP) and platelet-to-lymphocyte ratio (PLR) were associated with progressive atherosclerotic carotid artery stenosis (MPV, NLR), critical limb ischemia (CRP) and coronary artery disease (NLR, PLR)11–16. The gene discussed is CRP; the disease is coronary artery disorder.