We found that the concentrations of KIM-1 and IL-18 significantly higher in the PC-AKI group compared to the controls (P < 0.001), whereas they were lower in the PC-AKI with glycyrrhizin group compared to the PC-AKI group (KIM-1; P < 0.001 and IL-18; P = 0.008). This evidence concerns the gene IL18 and pachyonychia congenita.