The protein expression of intracellular (P < 0.001), cytoplasmic (P = 0.010) HMGB1 increased in the PC-AKI group compared to the controls, whereas the PC-AKI with glycyrrhizin group showed lower protein expression levels than the PC-AKI group (intracellular; P = 0.004; cytoplasmic; P = 0.008). The gene discussed is HMGB1; the disease is acute kidney injury.