The present study identified 576 significant DE-lncRNAs and 262 DE-mRNAs by high-throughput sequencing and confirmed that six RNAs (NR_028138.1, TCONS_00018621, TCONS_00002186, TNF, PID1, and SDK1) were significantly upregulated in BD patients compared with those in the control subjects. The gene discussed is PID1; the disease is Behcet disease.