In conclusion, our two cases of young adult women with massive brain artery thrombosis in addition to extensive systemic venous thrombosis, thrombocytopenia, and PF4–polyanion antibodies, developed within 10 days from ChAdOx1 nCov-19 vaccination, might represent a stroke variant of the recently named VITT syndrome. The gene discussed is PF4; the disease is Venous thrombosis.