Unfortunately, in HNSCC patients, elevated levels of Th2 cytokines IL-4, IL-6, and IL-10 generate an immunosuppressive state, creating an obstacle for targeted immunotherapy in oncogenic treatments.107 Increasing expression of EGF, IL-6, and IL-10 is associated with unfavorable patient outcomes.108. Here, EGF is linked to head and neck squamous cell carcinoma.