These cytokines induce signal transducer and activator of transcription 1 suppression, enhancing immune evasion in HNSCC.97 Inhibition of T lymphocytes, TAMs, NK cell, neutrophil activation, and DCs maturation by IL-6-mediated STAT3 activation has been correlated with poor survival and recurrence of HNSCC.98 Other immunosuppressive signaling pathways such as IL-10 also involve the transcription factor STAT3, resulting in a decrease in IL-12 expression,99 and differentiation of Treg cells100 in the TME. The gene discussed is STAT3; the disease is head and neck squamous cell carcinoma.