The MHC is a key element for the immune cells to recognize abnormal cells expressing tumor antigenic peptides to T lymphocytes.102 Cancer cells may evade CD8+ T-cell recognition through downregulation of MHC, allowing unrecognition of antigen.128 In this process, antigens are degraded through the cytoplasmic immuno-proteasome. This evidence concerns the gene HLA-C and neoplasm.