In contrast, HPV-driven tumors degrade p53, increase p16 expression, and inactivate Rb.6 Moreover, HPV− cancers commonly present with a loss of chromosome 9p, which is responsible for downregulation of p16 (CDKN2A) expression, and also duplication of chromosome 7p, promoting epidermal growth factor receptor (EGFR) overexpression. Here, RB1 is linked to cancer.