TBC1D24 and epilepsy: The determination of the three-dimensional structure of the TLDc domain from a fly orthologue of human TBC1D24 enabled the pathological mutations linked to human epilepsy to be mapped, and it was proposed that some of these mutations could impair the stability of the protein (Lüthy et al., 2019 ▸), illustrating that structural data on the TLDc domain could be of help in deciphering the impact of genetic mutations.