LRRK2 and Parkinson disease: However, it is important to note that extensive preclinical studies in vivo failed to detect any effects of LRRK2 inhibition on lung function (Baptista et al., 2020) and likewise, no deleterious effects have been reported for LRRK2 kinase inhibitors in clinical studies for Parkinson’s disease thus far (Biogen Denali Therapeutics Inc, 2021a; Biogen Denali Therapeutics Inc, 2021b).