Moreover, miR-138 inhibited cell migration, invasion and EMT in cancer via directly targeting rhomboid domain-containing protein 1 (RHBDD1) and Mowat-Wilson syndrome-associated transcription factor Zeb2 (Sip1/Zfhx1b), which decreased the E-Cadherin expression and increased the expression of N-Cadherin and Vimentin [57, 58]. This evidence concerns the gene RHBDD1 and cancer.