To better understand the roles of PSPC1 in tumor progression and develop therapeutic strategies to halt tumor metastasis, we also conducted integrated proteomics and transcriptomic analyses and found that PSPC1 is a contextual determinant of tumor progression to potentiate the reciprocal oncogenic switches of cytoplasmic protein-tyrosine kinase 6 (PTK6) and nuclear β-catenin subcellular translocation to augment Wnt3a autocrine signaling in tumor progression [27]. The gene discussed is PTK6; the disease is neoplasm.