We found that PSPC1 overexpression can also be a contextual activator to stimulate the nuclear translocation of β-catenin with enhanced interaction of PSPC1 and β-catenin in the nucleus and to upregulate Wnt3a autocrine signaling to potentiate synergistic oncogenic progression mediated by PSPC1 and PTK6 in HCC cells. This evidence concerns the gene WNT3A and hepatocellular carcinoma.