Finally, we provide genetic and functional evidence for a novel role of the TF, T-Box Transcription Factor 15 (TBX15), as one of the key master trans regulators of this WHRadjBMI co-expression network, advancing our understanding of how trans regulation of gene expression contributes to normal and obesity-deteriorated adipose tissue function, and the sexually dimorphic accumulation of harmful abdominal fat. The gene discussed is TBX15; the disease is obesity due to melanocortin 4 receptor deficiency.