We also provide insight into a WHRadjBMI co-expression network containing critical adipose TFs and GWAS genes that TBX15 regulates, and demonstrate the large contribution of the cis variants of these co-expression network genes to both WHRadjBMI PRS and T2D PRS in a sex-dependent manner in the UK Biobank. This evidence concerns the gene TBX15 and type 2 diabetes mellitus.