IFNA1 and infection: Upon IFN-α treatment, in Huh7.5-hSTAT2 cells, exogenous hSTAT2 dramatically augmented IFN signalling, resulting in an approximately 3-log reduction in Gluc activity, and the antiviral effect was diminished at late time points post infection (Figure 7(d)), probably due to the virus-induced degradation of hSTAT2-HA.