TSPO and schizophrenia: On the other hand, patients with chronic schizophrenia appear to demonstrate no changes in TSPO uptake outside of acute events, or increased uptake during symptomatic episodes of psychosis (Bloomfield et al., 2016, Conen et al., 2020, De Picker et al., 2019b, Di Biase et al., 2017, Takano et al., 2010) due to primed microglia.