For example, the studies have reported the disparate patterns for the localization of XRCC1 and its interacting partners to the sites of DNA damage and altered repair profiles of oxidative damage induced H2O2 in the XRCC1-deficient EM9 CHO cells expressing XRCC1 cancer-associated variants R194W, R280H, and R399Q (59, 64). The gene discussed is XRCC1; the disease is cancer.