Similarly, a large number of germline and cancer-associated SNP variants that affect amino acid composition of XRCC1 have been reported in the human population, and epidemiology studies have found an association of some of these with cancer risk (59, 60, 61, 62, 63, 64, 65, 66, 70, 71, 72, 73, 74). The gene discussed is XRCC1; the disease is cancer.