In contrast, low-permissive cell lines, such as the breast cancer HCC-1937, the colon adenocarcinoma CL-34, and esophageal squamous cell carcinoma KYSE-30 cell lines showed slow replication kinetics, which was also true for the oral squamous cell carcinoma cell lines UPCI-SCC-074 and UPCI-SCC-131 but not for the neuronal cells DBTRG-05MG and KELLY despite high levels of NRP1 (Fig 3A, S2 Fig). The gene discussed is NRP1; the disease is esophageal squamous cell carcinoma.