TMPRSS2 and hepatocellular carcinoma: Furthermore, missense variants were detected in TMPRSS2 for HCC-1937 (homozygous), CL-40 (heterozygous), CAL-33 (homozygous), and HDQ-P1 (heterozygous) (Fig 4B), namely V197M (V160M) in exon 6 (rs12329760) and/or G8V in exon 1 (rs75603675).