We determined that TEAD family members are essential for the ability of YAP and TAZ to induce lytic EBV reactivation, since the mutated YAP protein, YAP(5SA-S94A), which specifically cannot interact with TEADs, does not induce lytic reactivation, and co-transfection with a TEAD protein is required for the ability of both YAP and TAZ to induce lytic EBV reactivation in the Akata Burkitt lymphoma line (where YAP/TAZ and TEADs are not endogenously expressed) (Fig 10). The gene discussed is WWTR1; the disease is Burkitt lymphoma.