Increase in genes associated with intrinsic and common coagulation pathways, namely KNG1 and FGA, are upregulated early in both HTNV and ANDV infection (6 hpi to 2 dpi) and peak expression occurs coinciding with ANDV viremia (FGA >11 log2 fold on 10 and 12 dpi, KNG1 >4 log2 fold on 10 and 12 dpi) (Fig 8). The gene discussed is FGA; the disease is infection.