Human transthyretin (TTR) is a physiologicalprotein acting asa hormone carrier.68,69 Although some genetic variantsof TTR lead to a systemic amyloidosis called familial amyloid polyneuropathy,70 TTR is a potential drug carrier and has beenrecently proposed as a multivalency Fab platform for target clustering.71 The gene discussed is TTR; the disease is familial amyloid neuropathy.