CD4 and inflammatory bowel disease: In contrast to our findings, Lo et al. described that IBD samples showed higher CD8 + T cell and CD4 + T cell counts and similar CD68 + cell counts when compared to PD-1 CIC samples, as well as similar CD8 + T cell and CD4 + T cell counts and lower CD68 + cell counts when compared with CTLA-4 CIC [31].