Two types of pertussis vaccines are available: whole-cell vaccines based on killed B. pertussis organisms and acellular pertussis vaccines which include up to 5 highly purified pertussis antigens [always pertussis toxin (PT), and a different combination of pertactin (PRN), filamentous hemagglutinin (FHA), fimbriae types 2 and 3 (FIM2 and FIM3, respectively). The gene discussed is F2; the disease is pertussis.