Placentas from women with mild and severe COVID-19 have been shown to express higher levels of von Willebrand factor (vWf) with reduced levels of claudin-5 and VE-cadherin in the decidua and chorionic villi, revealing the presence of thrombosis, infarcts and vascular wall remodeling, but mainly in women with severe COVID-19 [140]. Here, CLDN5 is linked to COVID-19.