TTN and hypertrophic cardiomyopathy: For example, TCAP (regulates sarcomere assembly and titin assembly; implicated in familial hypertrophic cardiomyopathy), MYL3 (myosin light chain 3; implicated in left ventricular hypertrophic cardiomyopathy and restrictive cardiomyopathy), LDB3, and DES were highly downregulated (Figure 7C).