Proteins SAP3, NPS‐PLA2, IGFBP‐7, MIC‐1, TIMP‐4, and OPG have been reported to be associated with dementia in case‐control studies,27, 48, 49, 50, 51, 52, 53, 54 and TREM2 and N‐terminal pro‐BNP in prospective cohort studies,55, 56, 57 with all associations in the same direction as in this study. This evidence concerns the gene IGFBP7 and dementia.