YAP1 and neoplasm: Indeed, it has been shown that YAP is a central mediator of VEGF signaling in endothelial cells in which it contributes to angiogenesis (Wang et al., 2017; Azad et al., 2018; Elaimy and Mercurio, 2018), as well as in tumor cells (Zanconato et al., 2016; Elaimy and Mercurio, 2018).