The potential involvement of miR-31-5p in DUX4 downstream cascades is supported by the dysregulation of miR-31-5p in several inflammatory-related disorders such as cancer (Cho et al., 2015; Necela et al., 2011; Yi et al., 2019), psoriasis (Abdallah and Pichon, 2019; Xu et al., 2013), experimental autoimmune encephalomyelitis (Zhang et al., 2015), inflammatory bowel disease (Olaru et al., 2011), lupus (Dai et al., 2010) and asthma (Shi et al., 2019). The gene discussed is DUX4; the disease is asthma.