DUX4 and facioscapulohumeral muscular dystrophy: The data also revealed that chronic DUX4 expression induced hallmarks of FSHD pathology such as increased centrally nucleated myofibers (damaged, regenerated myofibers), immune infiltration and reduced muscle regeneration (Arahata et al., 1995; Banerji et al., 2020; Frisullo et al., 2011; Honda et al., 1987; Padberg, 1982; Statland et al., 2015b).