The class IIa HDAC inhibitor MC1568 (used in this study) has been reported to effectively reduce the severity and incidence of abdominal aortic aneurysms in angiotensin II–infused ApoE–/– mice by attenuating the expression of proinflammatory markers and restoring correct organization of elastin and collagen fibers (36). This evidence concerns the gene ELN and abdominal aortic aneurysm.