In this study, we aim to explore the role of CUL4B and miR-101-3p in PCA cells, as well as the mechanism of miR-101-3p/CUL4B/axis regulating PCA cells, and propose a hypothesis that miR-101-3p targets CUL4B expression can inhibit PCA progression through PI3K/AKT/mTOR signaling pathway. Here, CUL4B is linked to posterior cortical atrophy.