The experiment in vitro indicated that PCA cellular migrating, invasion and proliferating were inhibited through miR-101-3p inducing PCA cellular apoptosis via aiming for CUL4B, which might be related with PI3K/AKT/mTOR suppression, providing a new perspective for the pathogenesis of PCA, and at the same time a promising target for the clinical treatment of PCA. The gene discussed is CUL4B; the disease is posterior cortical atrophy.