NLRP1 and Alzheimer disease: In addition, many genes involved in immune response were identified as DEGs with increased abundance in astrocytes of both serum‐treated brain organoids and AD patient cortex, such as metallothionein‐2A (MT2A), nuclear paraspeckles assembly transcript 1 (NEAT1), peroxiredoxin‐6 (PRDX6), NACHT, LRR, and PYD domains‐containing protein 1 (NLRP1), and interferon‐induced transmembrane protein 3 (IFITM3) (Figure 7D).