Different studies have implicated an involvement of tumor necrosis factor‐alpha (TNF‐α), a pro‐inflammatory cytokine, in the pathophysiology of angiotensin II (AngII)‐dependent hypertension and the development of renal injury (Elmarakby et al., 2006; Guzik et al., 2007; Mehaffey & Majid, 2017; Nguyen et al., 2013; Satou et al., 2018; Zhang et al., 2014). This evidence concerns the gene AGT and Hypertension.