Then, we assessed the clinical relevance of PTCSC3 and found that PTCSC3 expression levels were reduced significantly in all stages of thyroid cancer compared with the peritumoral tissues, but there was no significant difference in PTCSC3 expression between clinical stages I/II and III/IV (Figure 1C,D), suggesting that PTCSC3 downregulation is an early event in PTC development. The gene discussed is PTCSC3; the disease is thyroid cancer.