AKT1 and heart disorder: Since PTEN negatively regulates PI3K/AKT while activation of Akt protects cardiomyocytes from apoptosis and heart function from cardiac injury (Fujio et al. 2000), inactivation of PTEN emerged as a potential therapeutic method against cardiac diseases, especially ischemic cardiac stress (Oudit et al. 2008; Ruan et al. 2009).