Indeed, mpMRI-detected tumours ostensibly harbour a greater proportion of molecular features of progression, including PTEN loss, biochemical recurrence (BCR)-associated genes (eg, CENPF), and elevated genomic scores (eg, Oncotype DX, Decipher, and Prolaris) compared to undetected disease [10], [29], thus reinforcing the potential prognostic utility of mpMRI conspicuity. This evidence concerns the gene PTEN and neoplasm.