The AUCs for discrimination of significant (ISUP grade ≥2) prostate cancer were 0.61 (95% confidence interval [CI] 0.56–0.65) for PSA, 0.70 (95% CI 0.66–0.74) for PSA density, and 0.77 (95% CI 0.73–0.80) for the Stockholm3 test. This evidence concerns the gene KLK3 and Familial prostate cancer.