TGM2 and Hepatic fibrosis: To explore the possibility of TG2 as a target to decrease liver fibrosis, TG2 knockout mice after CCl4-induced liver damage did not show a significant decrease in liver fibrosis when compared to wild-type mice; however, these animals were more susceptible to liver inflammation, which suggest a role of TG2 in control of both inflammation and fibrosis progression [91].