While TGF-β1, the major isoform in the liver, is associated with HSC activation and ECM production in liver fibrosis in general and TGF-β2 is associated with biliary liver disease, TGF-β3 might inhibit TGF-β1 and TGF-β2 expression [92–94]. Here, TGFB1 is linked to Hepatic fibrosis.