While TGF-β1, the major isoform in the liver, is associated with HSC activation and ECM production in liver fibrosis in general and TGF-β2 is associated with biliary liver disease, TGF-β3 might inhibit TGF-β1 and TGF-β2 expression [92–94]. This evidence concerns the gene TGFB2 and hepatobiliary disorder.