MT-CO1 and Gliosis: For comparison, 3 heteroplasmic mutations were identified in a total 3 of 10 gliosis samples and none of those were missense (1 rRNA mutation m.2140G>A at 6.9% heteroplasmy, 1 ND6 synonymous mutation m.14569G>A at 12% heteroplasmy, and 1 COX1 synonymous mutation m.6158A>G at 4.7% heteroplasmy).