PPARA and fatty liver disease: To investigate the consequence of the reduced GC production by the adrenal glands of ZBTB32−/− mice during starvation, in relation to the increase in body weight and fat volume, we examined several aspects of fat catabolism, including lipolytic activity in fat tissue, circulating free fatty acid (FFA) levels, hepatic PPARα-target gene expression, and hepatic steatosis.