Downregulation of miR-142-3p, miR-181d and miR-370-3p, and upregulation of miR-221/222, miR-370-3p, miR-409-3p, miR-603, miR-648 and miR-767-3p have been shown to inhibit MGMT suppression and promote chemoresistance in GBM cells[213,217-224]. The gene discussed is MGMT; the disease is glioblastoma.