Also, insulin-like growth factor 1 stimulates glioma proliferation by upregulating miR-513a-5p which acts to suppress expression of NEDD4L via PI3K signaling; this in turn prevents NEDD4L from inhibiting Wnt/β-catenin signaling and promotes GBM progression and chemoresistance[119]. The gene discussed is NEDD4L; the disease is central nervous system cancer.