Prometastatic chemokines CXCL8 (IL-8), CCL2 (monocyte chemoattractant protein-1 (MCP-1)), and CCL5 (RANTES) are upregulated in TNBC cell lines cocultured with primary CAFs from BC patients, acquiring invasive properties mediated by tumor necrosis factor-alpha- (TNF-α-) induced Notch1 activation [122, 123]. The gene discussed is TNF; the disease is breast cancer.