FOXP3+ is an indicator of Treg activity, tumor progression, and metastasis [62], with its suppression, together with programmed death 1 (PD1), T cell immunoglobulin mucin-3, and CTLA-4, assuring the increased immunotherapy response [61] (Figure 1), relapse-free survival (RFS), and overall survival (OS) in BC patients [63]. The gene discussed is CTLA4; the disease is breast cancer.