As shown in Figure 2, the levels of PINX1 mRNA expression were significantly upregulated in SLE patients compared with healthy controls (median, interquartile range of normalized fluorescence intensity: 20 healthy controls 389.7 374.0-427.3 vs. 61 SLE patients 484.6 426.4-566.0; P = 0.3∗10−4). This evidence concerns the gene PINX1 and systemic lupus erythematosus.