PRF1 and neoplasm: Hence, CAR-NK-92 cells exert its tumor killing mainly through (i) granule-mediated cytotoxicity via perforin and granzymes; (ii) death receptor-mediated apoptosis, involving FasL and TRAIL; and (iii) the secretion of proinflammatory cytokines and chemokines, e.g., TNF-α, IFN-Ɣ, and CCL3 [4, 18, 26, 27].