Together, our established CD19-NK-92 and CD138-NK-92 cells were highly specific to their antigens without showing cross-reactivity between CD19 and CD138 and were highly cytotoxic toward various corresponding hematologic cancer cells as both CAR-NK cytotoxicities were observed at a relatively low E : T ratio of 1 : 5 and at as early as 4 h postincubation. This evidence concerns the gene SDC1 and hematopoietic and lymphoid cell neoplasm.