It is revealed that the cancer cells could promote invasion in an MMP2-dependent manner following E-cadherin knockdown [48] As reported by Yan Wang et al., SEMA4D expression has been reported to be increased in esophagus squamous cell carcinoma (ESCC), and consistent with our results, SEMA4D knockdown could repress cell proliferation and migration in ESCC [49]. This evidence concerns the gene MMP2 and esophageal squamous cell carcinoma.