ACAP2 and esophageal cancer: It was reported that knockdown of ACAP2 blocks apoptosis in cancer cells in response to the chemotherapeutic antimetabolite 5-fluorouracil and that ACAP2 expression is downregulated in some esophageal cancers, leukemia, and lymphomas suggesting that ACAP2 inactivation or downregulation in human cells may contribute to cancer development [19].