In patients with OS, risk factors for CHD included hypertension, diabetes, stroke, BMI, LDH level, and tidal volume; risk factors for heart failure included diabetes, PTE, PO2, PCO2, MVV, and neutrophilic granulocyte percentage; and risk factors for PAH included PTE, PCO2, minSpO2, PCO2, and BNP and LDH levels. The gene discussed is NPPB; the disease is heart failure.