It is further evidenced that DXZ had similar effects to FER-1 on the DOX-induced rats as the treatments with both FER-1 and DXZ can reduce the cardiomyopathy induced by DOX; block the increase in the expression of PTGS2 and the markers of cardiac hypertrophy; and reduce the expressions of ANP, BNP, and MYH7 in the heart tissue induced by DOX. Here, NPPB is linked to cardiac hypertrophy.