In summary, identified lncRNA-co-expressed/nearby targeted mRNAs pairs including AC005392.3/AC007278.2-IL18R1, AL356356.1/AL137145.2-PFKFB3, and MKNK1-AS1/LINC01127-IL1R2 and several signaling pathways (TNF signaling pathway, cytokine–cytokine receptor interaction, fructose and mannose metabolism, HIF-1 signaling pathway, hematopoietic cell lineage, fluid shear stress and atherosclerosis, and estrogen signaling pathway) may be involved in the progression from AMI to MF to HF. The gene discussed is IL1R2; the disease is atherosclerosis.