TNF and atherosclerosis: In addition, several enriched signaling pathways in the KEGG analysis were identified, including TNF signaling pathway and cytokine–cytokine receptor interaction (involving IL18R1), fructose and mannose metabolism and HIF-1 signaling pathway (involving PFKFB3), hematopoietic cell lineage and fluid shear stress and atherosclerosis (involving IL1R2), and estrogen signaling pathway (involving FKBP5).