For example, IL18R1 was enriched in the TNF signaling pathway and cytokine–cytokine receptor interaction; PFKFB3 was enriched in fructose and mannose metabolism and HIF-1 signaling pathway; IL1R2 was enriched in hematopoietic cell lineage and fluid shear stress and atherosclerosis. The gene discussed is PFKFB3; the disease is atherosclerosis.