The role of ICT1 in the regulation of apoptosis has been shown in a large number of studies carried out on various types of cancer cells, which allows considering it as a universal mechanism (Wang et al., 2015; Lao et al., 2016; Wang et al., 2017a; Wang et al., 2017b; Chang et al., 2017; Chen et al., 2017; Xie et al., 2017; Li et al., 2018; Pan et al., 2021). Here, MRPL58 is linked to cancer.