The top 10 ranked genes in asthma were composed of eight upregulated genes [including CLCA1 (score = 4.99E-15), CPA3 (score = 1.21E-12), CST1 (score = 1.56E-11), PRR4 (score = 2.51E-11), SERPINB2 (score = 1.08E-08), POSTN (score = 3.57E-08), ITLN1 (score = 7.85E-08), UPK1B (score = 1.11E-07)] and two downregulated genes [including BPIFA1 (score = 3.52E-12), FHOD3 (score = 3.90E-08)]. This evidence concerns the gene PRR4 and asthma.