In addition to common mutations in TP53, we found a previously unknown recurrently mutated gene, KMT2D (also known as KMT2B, MLL2 and MLL4), which functions as a major enhancer regulator in various biological processes, including in the regulation of development, differentiation, metabolism, and tumor suppression (Froimchuk et al., 2017). Here, KMT2D is linked to neoplasm.