INS and metabolic disease: Insulin resistant and diabetic conditions induce the development of metabolic diseases by reducing the expression of BRD4-targeted carbohydrate-responsive metabolic genes in white adipose tissue and by inducing the expression of BRD4-targeted carbohydrate-responsive metabolic genes in the liver, small intestine, and innate leukocytes such as monocytes, macrophages, and neutrophils.