LRP6 and coronary artery disorder: Holdt et al. (2016) demonstrated that circ_ANRIL inhibits the proliferation and promotes the apoptosis of VSMCs and is associated with coronary artery disease. Hall et al. (2019) found circ_Lrp6 is a sponge for miR-145 and circ_Lrp6 hindered miR-145-mediated regulation of VSMC migration, proliferation, and differentiation, furthermore, the ratio of circ_Lrp6 bound to miR-145 versus unbound could play a role in vascular pathogenesis.